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  E35. The method of embodiment 33, wherein the molecule is
  administered to the brain of the mammal. E49. The method of embodiment 48, wherein the disease or a condition is selected from the group consisting of a viral
  infection, a neurological disorder (e.g., Alzheimer's disease,
  progressive supranuclear palsy, Down syndrome, dementia pugilistica (chronic
  traumatic encephalopathy and other traumatic brain injury), frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), Huntington's
  disease, Rett Syndrome, Angelman Syndrome, Lytico-Bodig disease (Parkinson-dementia complex
  of Guam), Tangle-predominant dementia, ganglioglioma, gangliocytoma, meningioangiomatosis, subacute sclerosing panencephalitis,
  lead encephalopathy, Hemimegalencephaly, tuberous sclerosis, Hallervorden-Spatz disease,
  Pick's disease, corticobasal ganglionic degeneration, argyrophilic grain disease, corticobasal degeneration, lipofuscinosis, frontotemporal dementia, supranuclear palsy, and frontotemporal lobar degeneration,
  a disease of brain network dysfunction (e.g., all forms of epilepsy and depression), a spinal cord disorder, a peripheral neuropathy,
  a cranial nerve disorder (e.g., Trigeminal neuralgia), an autonomic nervous system disorder (e.g.,
  dysautonomia or multiple system atrophy), a movement disorder of a
  central and peripheral nervous system (e.g., Parkinson's
  disease, essential tremor, amyotrophic lateral sclerosis, Tourette's Syndrome, multiple sclerosis or various types of peripheral
  neuropathy), a sleep disorder (e.g., Narcolepsy), migraine or other types of headache
  (e.g., cluster headache and tension headache), lower back and neck pain, central neuropathy, a neuropsychiatric illness, attention deficit hyperactivity disorder, autism, Huntington's disease, organic
  psychosis, an infection of the brain or spinal cord (including meningitis), or
  a prion disease), anemia, cancer, leukemia, an inflammatory condition or
  an autoimmune disease (e.g. arthritis, psoriasis, lupus erythematosus,
  multiple sclerosis), a bacterial infection, frontotemporal
  dementia-tau (FTD-tau), frontotemporal dementia
  and parkinsonism linked to chromosome 17 (FTDP-17), corticobasal degeneration (CBD), traumatic
  brain injury, chronic traumatic encephalopathy, HIV associated neurocognitive disorders, Argyrophilic grain disease, Down syndrome-Alzheimer's disease, Amnestic mild
  cognitive impairment-Alzheimer's disease, Parkinson's disease dementia, Hallervorden-Spatz disease
  (Pantothenate kinase-associated neurodegeneration), Niemann Pick disease type C, Myotonic dystrophy, Amyotrophic lateral sclerosis, Hemimegalencephaly, Tuberous sclerosis complex, Focal cortical dysplasia type 2b,
  Ganglion cell tumors, Dravet Syndrome (severe
  myoclonic epilepsy of infancy), Temporal lobe epilepsy,
  Ohtahara syndrome (early infantile epileptic
  encephalopathy with suppression bursts), Lafora body disease, Generalized epilepsy with febrile seizures, Infantile spasms (West syndrome), Lennox
  Gastaut syndrome, Angelman Syndrome, Rett Syndrome, Landau Kleffner syndrome, focal seizures, simple focal seizures (no loss
  of consciousness), focal dyscognitive seizures (impairment of consciousness), focal seizure evolving to generalised
  tonic-clonic (GTC) convulsions, generalised seizures (convulsive or non-convulsive with
  bilateral discharges involving subcortical structures),
  absence seizures, myoclonic seizures, clonic seizures, tonic seizures, tonic-clonic seizures and atonic seizures, an autistic disorder, an autism spectrum disorder, an Asperger's disorder, a pervasive developmental disorder,
  and any combination thereof.
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